activation of protein kinase A activity, anatomical structure morphogenesis, camera-type eye development, cell adhesion mediated by integrin, cellular protein metabolic process, cellular response to insulin-like growth factor stimulus, cellular response to transforming growth factor beta stimulus, embryonic eye morphogenesis, extracellular matrix organization, glucose homeostasis, glucose metabolic process, heart development, metanephros development, negative regulation of osteoclast development, negative regulation of osteoclast differentiation, post-embryonic eye morphogenesis, post-translational protein modification, protein kinase A signaling, sequestering of BMP in extracellular matrix, sequestering of TGFbeta in extracellular matrix, skeletal system development
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
49
lipase activity, sterol esterase activity
399
Cholesteryl esterase, Lipase A, Sterol esterase
LIPA
9606
cytosol, fibrillar center, intracellular membrane-bounded organelle, lysosomal lumen, lysosome, nucleoplasm
cell morphogenesis, cell population proliferation, homeostasis of number of cells within a tissue, inflammatory response, lipid catabolic process, low-density lipoprotein particle clearance, lung development, sterol metabolic process, tissue remodeling
anterior neural tube closure, apoptotic DNA fragmentation, apoptotic process, apoptotic signaling pathway, axonal fasciculation, B cell homeostasis, cell fate commitment, cellular response to DNA damage stimulus, cellular response to staurosporine, cytokine-mediated signaling pathway, erythrocyte differentiation, execution phase of apoptosis, extrinsic apoptotic signaling pathway in absence of ligand, glial cell apoptotic process, heart development, hippo signaling, hippocampus development, intrinsic apoptotic signaling pathway in response to osmotic stress, keratinocyte differentiation, learning or memory, leukocyte apoptotic process, luteolysis, negative regulation of activated T cell proliferation, negative regulation of apoptotic process, negative regulation of B cell proliferation, neuron apoptotic process, neuron differentiation, neurotrophin TRK receptor signaling pathway, platelet formation, positive regulation of amyloid-beta formation, positive regulation of apoptotic process, positive regulation of neuron apoptotic process, protein processing, proteolysis, regulation of macroautophagy, regulation of protein stability, response to amino acid, response to antibiotic, response to cobalt ion, response to drug, response to estradiol, response to glucocorticoid, response to glucose, response to hydrogen peroxide, response to hypoxia, response to lipopolysaccharide, response to nicotine, response to tumor necrosis factor, response to UV, response to X-ray, sensory perception of sound, striated muscle cell differentiation, T cell homeostasis, wound healing
animal organ morphogenesis, cellular response to leukemia inhibitory factor, induction of positive chemotaxis, morphogenesis of embryonic epithelium, negative regulation of blood pressure, negative regulation of osteoblast differentiation, platelet degranulation, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of endothelial cell proliferation, positive regulation of lymphangiogenesis, positive regulation of mast cell chemotaxis, positive regulation of mesenchymal stem cell proliferation, positive regulation of neuroblast proliferation, positive regulation of protein autophosphorylation, positive regulation of protein kinase activity, positive regulation of protein phosphorylation, positive regulation of protein secretion, regulation of vascular endothelial growth factor receptor signaling pathway, response to drug, response to hypoxia, signal transduction, sprouting angiogenesis, substrate-dependent cell migration, vascular endothelial growth factor receptor signaling pathway, vascular endothelial growth factor signaling pathway
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
101
lipopolysaccharide binding
170
18 kDa cationic antimicrobial protein
CAMP
9606
extracellular exosome, extracellular region, extracellular space, specific granule, specific granule lumen, tertiary granule lumen
antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, antimicrobial humoral response, chronic inflammatory response, cytolysis by host of symbiont cells, defense response to bacterium, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, innate immune response, innate immune response in mucosa, killing by host of symbiont cells, modulation of process of other organism, neutrophil degranulation, positive regulation of interleukin-8 production, response to yeast
aging, COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, immune response, negative regulation of myelination, neutrophil degranulation, positive regulation of apoptotic signaling pathway, positive regulation of microglial cell activation, positive regulation of proteolysis involved in cellular protein catabolic process, proteolysis, proteolysis involved in cellular protein catabolic process, response to organic substance, T cell mediated cytotoxicity
axon, cell surface, cytoplasmic vesicle membrane, dendrite, early endosome, endoplasmic reticulum lumen, endosome, endosome membrane, Golgi apparatus, Golgi-associated vesicle lumen, hippocampal mossy fiber to CA3 synapse, integral component of membrane, integral component of plasma membrane, late endosome, lysosome, membrane, membrane raft, multivesicular body, neuronal cell body, plasma membrane, recycling endosome, synaptic vesicle, trans-Golgi network
amyloid fibril formation, amyloid precursor protein catabolic process, amyloid-beta formation, amyloid-beta metabolic process, cellular response to amyloid-beta, cellular response to copper ion, cellular response to manganese ion, detection of mechanical stimulus involved in sensory perception of pain, membrane protein ectodomain proteolysis, positive regulation of neuron apoptotic process, prepulse inhibition, protein processing, proteolysis, regulation of synaptic vesicle exocytosis, response to lead ion, response to radiation
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
13
peptidase activity, RNA binding
110
Preproteolysin
DCD
9606
extracellular exosome, extracellular region, extracellular space
antimicrobial humoral immune response mediated by antimicrobial peptide, antimicrobial humoral response, defense response to bacterium, defense response to fungus, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, killing by host of symbiont cells, killing of cells of other organism
apical plasma membrane, extracellular region, extracellular space, glutamatergic synapse, integral component of membrane, integral component of postsynaptic density membrane, integral component of presynaptic active zone membrane, membrane, nucleoplasm, plasma membrane
activation of MAPK activity, activation of protein kinase B activity, activation of transmembrane receptor protein tyrosine kinase activity, animal organ development, cardiac muscle cell differentiation, cardiac muscle cell myoblast differentiation, cell communication, cell differentiation, cell population proliferation, cellular protein complex disassembly, endocardial cell differentiation, ERBB signaling pathway, ERBB2 signaling pathway, ERBB3 signaling pathway, ERBB4 signaling pathway, intracellular signal transduction, mammary gland development, MAPK cascade, negative regulation of cardiac muscle cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of secretion, negative regulation of transcription, DNA-templated, nervous system development, neural crest cell development, positive regulation of cardiac muscle cell proliferation, positive regulation of cell adhesion, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of peptidyl-tyrosine autophosphorylation, positive regulation of protein kinase B signaling, positive regulation of protein-containing complex assembly, positive regulation of striated muscle cell differentiation, regulation of cell motility, regulation of postsynaptic neurotransmitter receptor internalization, synaptic membrane adhesion, transmembrane receptor protein tyrosine kinase signaling pathway, ventricular cardiac muscle cell differentiation, ventricular trabecula myocardium morphogenesis, wound healing