Details of PSQ01363
| ProSeqID |
PSQ01363 |
| Family |
FD00126 |
| Protein Name |
Beta-secretase 1 |
| UniProt ID |
P56817
|
| Taxonomy |
Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Primates-Haplorrhini-Catarrhini-Hominidae-Homo |
| Organisms |
Homo sapiens (Human) |
| Prosequence Length (aa) |
24 |
| Functions |
amyloid-beta binding, aspartic-type endopeptidase activity, endopeptidase activity, enzyme binding, peptidase activity |
| Preproprotein Length (aa) |
501 |
| Alt Name |
Aspartyl protease 2 , Beta-site amyloid precursor protein cleaving enzyme 1, Memapsin-2 , Membrane-associated aspartic protease 2 |
| Gene Name |
BACE1 |
| NCBI ID |
9606 |
| Cellular Localization |
axon, cell surface, cytoplasmic vesicle membrane, dendrite, early endosome, endoplasmic reticulum lumen, endosome, endosome membrane, Golgi apparatus, Golgi-associated vesicle lumen, hippocampal mossy fiber to CA3 synapse, integral component of membrane, integral component of plasma membrane, late endosome, lysosome, membrane, membrane raft, multivesicular body, neuronal cell body, plasma membrane, recycling endosome, synaptic vesicle, trans-Golgi network |
| Processes |
amyloid fibril formation, amyloid precursor protein catabolic process, amyloid-beta formation, amyloid-beta metabolic process, cellular response to amyloid-beta, cellular response to copper ion, cellular response to manganese ion, detection of mechanical stimulus involved in sensory perception of pain, membrane protein ectodomain proteolysis, positive regulation of neuron apoptotic process, prepulse inhibition, protein processing, proteolysis, regulation of synaptic vesicle exocytosis, response to lead ion, response to radiation |
| PubMed |
10591214
|
| Total Prosequence Length (aa) |
24 |
| Prosequence Location |
22:45 |
| Prosequence Sequence |
TQHGIRLPLRSGLGGAPLGLRLPR |
| Preproprotein Sequence |
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK |
