Details of family id : FD00039
| Family ID |
FD00039 |
| Protein Name |
Collagenase 3; Stromelysin-1; Interstitial collagenase; Macrophage metalloelastase |
| UniProt ID |
P33435
P45452
P03957
P21692
P34960
P03956
|
| Prosequence Length Range (aa) |
80-85
|
| Preproprotein Length Range(aa) |
469-480 |
| Preproprotein pI Range |
5.12-9.1 |
| Preproprotein Molecular Weight Range (D) |
53427.6-54971.13 |
| Prosequence pI Range (D) |
4.39-8.75 |
| Prosequence Molecular Weight Range |
8969.21-9547.7 |
| Domains |
cd00094 : pfam00413 : pfam01471 |
| Organisms |
Mus musculus (Mouse); Homo sapiens (Human); Rattus norvegicus (Rat); Sus scrofa (Pig) |
| Functions |
calcium ion binding; calcium-dependent protein binding; collagen binding; endopeptidase activity; fibronectin binding; low-density lipoprotein particle receptor binding; metalloendopeptidase activity; peptidase activity; zinc ion binding; metallopeptidase activity; protein-containing complex binding; serine-type endopeptidase activity; core promoter sequence-specific DNA binding; sequence-specific DNA binding |
| Cellular Localization |
extracellular matrix; extracellular region; extracellular space; Golgi apparatus; intercellular canaliculus; lysosome; cell body; cytosol; dendrite; mitochondrion; nucleus; protein-containing complex; cytoplasm |
| Processes |
bone mineralization; bone morphogenesis; cartilage development; cellular protein metabolic process; collagen catabolic process; endochondral ossification; extracellular matrix disassembly; extracellular matrix organization; growth plate cartilage development; heart development; peptide catabolic process; positive regulation of pancreatic trypsinogen secretion; proteolysis; response to hormone; response to amyloid-beta; cellular response to amino acid stimulus; cellular response to cell-matrix adhesion; cellular response to interleukin-1; cellular response to UV-A; female pregnancy; negative regulation of hydrogen peroxide metabolic process; negative regulation of protein kinase B signaling; positive regulation of cell migration; positive regulation of oxidative stress-induced cell death; positive regulation of protein-containing complex assembly; protein catabolic process; regulation of cell migration; response to amino acid; response to cytokine; response to estradiol; response to hypoxia; response to interleukin-1; response to lipopolysaccharide; response to mechanical stimulus; response to tumor necrosis factor; wound healing; bronchiole development; cellular response to virus; elastin catabolic process; lung alveolus development; negative regulation of endothelial cell-matrix adhesion via fibronectin; negative regulation of transcription by RNA polymerase II; negative regulation of type I interferon-mediated signaling pathway; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of gene expression; positive regulation of interferon-alpha production; positive regulation of transcription by RNA polymerase II; positive regulation of type I interferon-mediated signaling pathway; protein import into nucleus; regulation of defense response to virus by host; regulation of trophoblast cell migration; spreading of epidermal cells; cytokine-mediated signaling pathway; leukocyte migration; viral process |
| Common Name |
Collagenase; Stromelysin; collagenase; macrophage metalloelastase |
