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Details of PSQ01290

ProSeqID PSQ01290
Family FD00131
Protein Name Caspase-3
UniProt ID P42574
Taxonomy Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Primates-Haplorrhini-Catarrhini-Hominidae-Homo
Organisms Homo sapiens (Human)
Prosequence Length (aa) 19
Functions aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, death receptor binding, peptidase activity, phospholipase A2 activator activity, protease binding, protein-containing complex binding
Preproprotein Length (aa) 277
Alt Name Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1
Gene Name CASP3
NCBI ID 9606
Cellular Localization cytoplasm, cytosol, death-inducing signaling complex, membrane raft, neuronal cell body, nucleoplasm, nucleus
Processes anterior neural tube closure, apoptotic DNA fragmentation, apoptotic process, apoptotic signaling pathway, axonal fasciculation, B cell homeostasis, cell fate commitment, cellular response to DNA damage stimulus, cellular response to staurosporine, cytokine-mediated signaling pathway, erythrocyte differentiation, execution phase of apoptosis, extrinsic apoptotic signaling pathway in absence of ligand, glial cell apoptotic process, heart development, hippo signaling, hippocampus development, intrinsic apoptotic signaling pathway in response to osmotic stress, keratinocyte differentiation, learning or memory, leukocyte apoptotic process, luteolysis, negative regulation of activated T cell proliferation, negative regulation of apoptotic process, negative regulation of B cell proliferation, neuron apoptotic process, neuron differentiation, neurotrophin TRK receptor signaling pathway, platelet formation, positive regulation of amyloid-beta formation, positive regulation of apoptotic process, positive regulation of neuron apoptotic process, protein processing, proteolysis, regulation of macroautophagy, regulation of protein stability, response to amino acid, response to antibiotic, response to cobalt ion, response to drug, response to estradiol, response to glucocorticoid, response to glucose, response to hydrogen peroxide, response to hypoxia, response to lipopolysaccharide, response to nicotine, response to tumor necrosis factor, response to UV, response to X-ray, sensory perception of sound, striated muscle cell differentiation, T cell homeostasis, wound healing
PubMed 7596430
Total Prosequence Length (aa) 19
Prosequence Location 10:28
Prosequence Sequence SKSIKNLEPKIIHGSESMD
Preproprotein Sequence MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH