Details of PSQ01325
| ProSeqID |
PSQ01325 |
| Family |
FD00481 |
| Protein Name |
Caspase-4 |
| UniProt ID |
P49662
|
| Taxonomy |
Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Primates-Haplorrhini-Catarrhini-Hominidae-Homo |
| Organisms |
Homo sapiens (Human) |
| Prosequence Length (aa) |
19 |
| Functions |
CARD domain binding, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| Preproprotein Length (aa) |
377 |
| Alt Name |
ICE and Ced-3 homolog 2 , ICE(rel)-II , Mih1 , Protease TX |
| Gene Name |
CASP4 |
| NCBI ID |
9606 |
| Cellular Localization |
AIM2 inflammasome complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, IPAF inflammasome complex, mitochondrion, NLRP3 inflammasome complex, plasma membrane, protein-containing complex |
| Processes |
apoptotic process, cellular response to amyloid-beta, execution phase of apoptosis, inflammatory response, innate immune response, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, positive regulation of tumor necrosis factor-mediated signaling pathway, protein autoprocessing, proteolysis, pyroptosis, regulation of apoptotic process, regulation of inflammatory response |
| PubMed |
7797510
|
| Total Prosequence Length (aa) |
19 |
| Prosequence Location |
271:289 |
| Prosequence Sequence |
SPASLEVASSQSSENLEED |
| Preproprotein Sequence |
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN |
