Details of family id : FD00126
| Family ID |
FD00126 |
| Protein Name |
Beta-secretase 2; Beta-secretase 1 |
| UniProt ID |
Q9Y5Z0
P56817
|
| Prosequence Length Range (aa) |
24-42
|
| Preproprotein Length Range(aa) |
501-518 |
| Preproprotein pI Range |
5.05-5.31 |
| Preproprotein Molecular Weight Range (D) |
55763.79-56180.45 |
| Prosequence pI Range (D) |
6.81-12.48 |
| Prosequence Molecular Weight Range |
2536.02-4184.81 |
| Domains |
cd05473 |
| Organisms |
Homo sapiens (Human) |
| Functions |
aspartic-type endopeptidase activity; amyloid-beta binding; endopeptidase activity; enzyme binding; peptidase activity |
| Cellular Localization |
dense core granule; endoplasmic reticulum; endosome; Golgi apparatus; integral component of membrane; membrane; plasma membrane; trans-Golgi network; axon; cell surface; cytoplasmic vesicle membrane; dendrite; early endosome; endoplasmic reticulum lumen; endosome membrane; Golgi-associated vesicle lumen; hippocampal mossy fiber to CA3 synapse; integral component of plasma membrane; late endosome; lysosome; membrane raft; multivesicular body; neuronal cell body; recycling endosome; synaptic vesicle |
| Processes |
amyloid-beta metabolic process; astrocyte activation; glucose homeostasis; membrane protein ectodomain proteolysis; negative regulation of amyloid precursor protein biosynthetic process; peptide hormone processing; proteolysis; amyloid fibril formation; amyloid precursor protein catabolic process; amyloid-beta formation; cellular response to amyloid-beta; cellular response to copper ion; cellular response to manganese ion; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of neuron apoptotic process; prepulse inhibition; protein processing; regulation of synaptic vesicle exocytosis; response to lead ion; response to radiation |
| Common Name |
Beta secretase |
