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Details of PSQ01595

ProSeqID PSQ01595
Family FD00155
Protein Name Pro-neuregulin-1
UniProt ID Q02297
Taxonomy Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Primates-Haplorrhini-Catarrhini-Hominidae-Homo
Organisms Homo sapiens (Human)
Prosequence Length (aa) 19
Functions chemorepellent activity, cytokine activity, ErbB-3 class receptor binding, growth factor activity, integrin binding, protein tyrosine kinase activator activity, receptor tyrosine kinase binding, signaling receptor binding, transcription coregulator activity, transmembrane receptor protein tyrosine kinase activator activity
Preproprotein Length (aa) 640
Alt Name None
Gene Name NRG1
NCBI ID 9606
Cellular Localization apical plasma membrane, extracellular region, extracellular space, glutamatergic synapse, integral component of membrane, integral component of postsynaptic density membrane, integral component of presynaptic active zone membrane, membrane, nucleoplasm, plasma membrane
Processes activation of MAPK activity, activation of protein kinase B activity, activation of transmembrane receptor protein tyrosine kinase activity, animal organ development, cardiac muscle cell differentiation, cardiac muscle cell myoblast differentiation, cell communication, cell differentiation, cell population proliferation, cellular protein complex disassembly, endocardial cell differentiation, ERBB signaling pathway, ERBB2 signaling pathway, ERBB3 signaling pathway, ERBB4 signaling pathway, intracellular signal transduction, mammary gland development, MAPK cascade, negative regulation of cardiac muscle cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of secretion, negative regulation of transcription, DNA-templated, nervous system development, neural crest cell development, positive regulation of cardiac muscle cell proliferation, positive regulation of cell adhesion, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of peptidyl-tyrosine autophosphorylation, positive regulation of protein kinase B signaling, positive regulation of protein-containing complex assembly, positive regulation of striated muscle cell differentiation, regulation of cell motility, regulation of postsynaptic neurotransmitter receptor internalization, synaptic membrane adhesion, transmembrane receptor protein tyrosine kinase signaling pathway, ventricular cardiac muscle cell differentiation, ventricular trabecula myocardium morphogenesis, wound healing
PubMed 7689552
Total Prosequence Length (aa) 19
Prosequence Location 1:19
Prosequence Sequence MSERKEGRGKGKGKKKERG
Preproprotein Sequence MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV