Details of family id : FD00155
| Family ID |
FD00155 |
| Protein Name |
Pro-neuregulin-1 |
| UniProt ID |
Q02297
P43322
|
| Prosequence Length Range (aa) |
13-19
|
| Preproprotein Length Range(aa) |
640-662 |
| Preproprotein pI Range |
9.0-9.01 |
| Preproprotein Molecular Weight Range (D) |
70391.8-73288.05 |
| Prosequence pI Range (D) |
10.28-10.64 |
| Prosequence Molecular Weight Range |
1419.62-2146.5 |
| Domains |
cd05895 : pfam02158 |
| Organisms |
Homo sapiens (Human); Rattus norvegicus (Rat) |
| Functions |
chemorepellent activity; cytokine activity; ErbB-3 class receptor binding; growth factor activity; integrin binding; protein tyrosine kinase activator activity; receptor tyrosine kinase binding; signaling receptor binding; transcription coregulator activity; transmembrane receptor protein tyrosine kinase activator activity; ErbB-2 class receptor binding |
| Cellular Localization |
apical plasma membrane; extracellular region; extracellular space; glutamatergic synapse; integral component of membrane; integral component of postsynaptic density membrane; integral component of presynaptic active zone membrane; membrane; nucleoplasm; plasma membrane; axolemma; axon; cell body; cytoplasm; dendrite; external side of plasma membrane; GABA-ergic synapse; integral component of plasma membrane; neuromuscular junction; nucleus; synapse |
| Processes |
activation of MAPK activity; activation of protein kinase B activity; activation of transmembrane receptor protein tyrosine kinase activity; animal organ development; cardiac muscle cell differentiation; cardiac muscle cell myoblast differentiation; cell communication; cell differentiation; cell population proliferation; cellular protein complex disassembly; endocardial cell differentiation; ERBB signaling pathway; ERBB2 signaling pathway; ERBB3 signaling pathway; ERBB4 signaling pathway; intracellular signal transduction; mammary gland development; MAPK cascade; negative regulation of cardiac muscle cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of secretion; negative regulation of transcription; DNA-templated; nervous system development; neural crest cell development; positive regulation of cardiac muscle cell proliferation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein-containing complex assembly; positive regulation of striated muscle cell differentiation; regulation of cell motility; regulation of postsynaptic neurotransmitter receptor internalization; synaptic membrane adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; ventricular cardiac muscle cell differentiation; ventricular trabecula myocardium morphogenesis; wound healing; axon ensheathment; brain development; cardiac conduction system development; cardiac muscle tissue development; cell migration; cell morphogenesis; chemorepulsion involved in interneuron migration from the subpallium to the cortex; glial cell differentiation; glial cell fate commitment; heart development; locomotory behavior; memory; muscle organ development; myelination in peripheral nervous system; negative regulation of corticosterone secretion; negative regulation of neuron migration; negative regulation of protein catabolic process; neurogenesis; neuron fate commitment; neurotransmitter receptor metabolic process; oligodendrocyte differentiation; peripheral nervous system development; positive regulation of axon extension; positive regulation of axon regeneration; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle cell differentiation; positive regulation of dendritic spine development; positive regulation of gene expression; positive regulation of myelination; positive regulation of neuron projection development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein localization to cell surface; positive regulation of Ras protein signal transduction; positive regulation of Schwann cell proliferation; positive regulation of transcription by RNA polymerase II; postsynapse to nucleus signaling pathway; regulation of cell differentiation; response to progesterone; startle response; synapse assembly |
| Common Name |
neuregulin |
