Details of family id : FD00416
| Family ID |
FD00416 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 17 |
| UniProt ID |
P78536
|
| Prosequence Length Range (aa) |
197
|
| Preproprotein Length Range(aa) |
824 |
| Preproprotein pI Range |
5.5 |
| Preproprotein Molecular Weight Range (D) |
93020.96 |
| Prosequence pI Range (D) |
6.44 |
| Prosequence Molecular Weight Range |
22915.91 |
| Domains |
cd04270 : cl03265 : pfam16698 : smart00050 |
| Organisms |
Homo sapiens (Human) |
| Functions |
endopeptidase activity; integrin binding; interleukin-6 receptor binding; metal ion binding; metalloendopeptidase activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; metallopeptidase activity; Notch binding; PDZ domain binding; peptidase activity; SH3 domain binding |
| Cellular Localization |
actin cytoskeleton; apical plasma membrane; cell surface; cytoplasm; cytosol; endoplasmic reticulum lumen; Golgi membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane |
| Processes |
amyloid precursor protein catabolic process; B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility; cellular response to high density lipoprotein particle stimulus; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; germinal center formation; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of cold-induced thermogenesis; negative regulation of inflammatory response to antigenic stimulus; negative regulation of transforming growth factor beta receptor signaling pathway; neutrophil mediated immunity; Notch receptor processing; Notch signaling pathway; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cellular component movement; positive regulation of chemokine production; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of leukocyte chemotaxis; positive regulation of protein phosphorylation; positive regulation of T cell chemotaxis; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of vascular endothelial cell proliferation; protein processing; proteolysis; receptor transactivation; regulation of mast cell apoptotic process; response to drug; response to hypoxia; response to lipopolysaccharide; spleen development; T cell differentiation in thymus; tumor necrosis factor-mediated signaling pathway; wound healing; spreading of epidermal cells |
| Common Name |
Disintegrin and metalloproteinase domain containing protein |
