bone resorption, central nervous system development, epithelial cell differentiation, IRE1-mediated unfolded protein response, lipid metabolic process, lysosomal protein catabolic process, lysosome organization, nervous system development, neuromuscular process controlling balance, peptide catabolic process, protein catabolic process, protein localization to chromosome, telomeric region, proteolysis
adult walking behavior, aging, cellular protein catabolic process, cellular response to growth factor stimulus, cellular response to heat, cellular response to interferon-beta, cellular response to oxidative stress, cellular response to retinoic acid, ceramide metabolic process, execution phase of apoptosis, forebrain development, intrinsic apoptotic signaling pathway in response to DNA damage, mitochondrion organization, negative regulation of cell cycle, negative regulation of mitophagy in response to mitochondrial depolarization, negative regulation of neuron death, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, neuron development, pentacyclic triterpenoid metabolic process, positive regulation of apoptotic process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of mitochondrion organization, positive regulation of protein targeting to mitochondrion, programmed cell death, protein autoprocessing, proteolysis, regulation of autophagy of mitochondrion, regulation of multicellular organism growth, response to herbicide
defense response to virus, extrinsic apoptotic signaling pathway, interleukin-33-mediated signaling pathway, microglial cell activation involved in immune response, microglial cell proliferation, negative regulation of immunoglobulin production, negative regulation of interferon-gamma production, negative regulation of leukocyte migration, negative regulation of macrophage proliferation, negative regulation of T-helper 1 type immune response, negative regulation of transcription by RNA polymerase II, positive regulation of CD80 production, positive regulation of CD86 production, positive regulation of cellular defense response, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of gene expression, positive regulation of immunoglobulin production, positive regulation of inflammatory response, positive regulation of interleukin-13 production, positive regulation of interleukin-4 production, positive regulation of interleukin-5 production, positive regulation of interleukin-6 production, positive regulation of macrophage activation, positive regulation of MHC class I biosynthetic process, positive regulation of MHC class II biosynthetic process, positive regulation of neuroinflammatory response, positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type 2 immune response, protein deubiquitination
acute-phase response, antimicrobial humoral immune response mediated by antimicrobial peptide, blood coagulation, blood coagulation, intrinsic pathway, cell surface receptor signaling pathway, cellular protein metabolic process, cytolysis by host of symbiont cells, endoplasmic reticulum to Golgi vesicle-mediated transport, fibrinolysis, G protein-coupled receptor signaling pathway, leukocyte migration, multicellular organism development, negative regulation of astrocyte differentiation, negative regulation of cytokine production involved in inflammatory response, negative regulation of fibrinolysis, negative regulation of platelet activation, negative regulation of proteolysis, neutrophil-mediated killing of gram-negative bacterium, platelet activation, positive regulation of blood coagulation, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of collagen biosynthetic process, positive regulation of lipid kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of protein localization to nucleus, positive regulation of protein phosphorylation, positive regulation of reactive oxygen species metabolic process, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of release of sequestered calcium ion into cytosol, proteolysis, regulation of blood coagulation, regulation of cell shape, regulation of complement activation, regulation of cytosolic calcium ion concentration, response to wounding
activation of phospholipase C activity, adenylate cyclase-activating G protein-coupled receptor signaling pathway, bone resorption, cAMP metabolic process, cell-cell signaling, cellular calcium ion homeostasis, cellular macromolecule biosynthetic process, G protein-coupled receptor signaling pathway, homeostasis of number of cells within a tissue, hormone-mediated apoptotic signaling pathway, magnesium ion homeostasis, negative regulation of apoptotic process in bone marrow cell, negative regulation of bone mineralization involved in bone maturation, negative regulation of chondrocyte differentiation, negative regulation of gene expression, negative regulation of inflammatory response to antigenic stimulus, phosphate ion homeostasis, positive regulation of bone mineralization, positive regulation of cell proliferation in bone marrow, positive regulation of glucose import, positive regulation of glycogen biosynthetic process, positive regulation of inositol phosphate biosynthetic process, positive regulation of osteoclast proliferation, positive regulation of signal transduction, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to cadmium ion, response to drug, response to ethanol, response to fibroblast growth factor, response to lead ion, response to parathyroid hormone, response to vitamin D, Rho protein signal transduction, skeletal system development
adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cellular response to glucagon stimulus, feeding behavior, G protein-coupled receptor signaling pathway, glucose homeostasis, negative regulation of apoptotic process, negative regulation of execution phase of apoptosis, negative regulation of inflammatory response to antigenic stimulus, positive regulation of calcium ion import, positive regulation of ERK1 and ERK2 cascade, positive regulation of gluconeogenesis, positive regulation of histone H3-K4 methylation, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-threonine phosphorylation, positive regulation of protein binding, positive regulation of protein kinase activity, protein kinase A signaling, regulation of insulin secretion, response to activity
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
112
copper ion binding, cytokine activity, interleukin-1 receptor binding
271
Hematopoietin-1
IL1A
9606
cytosol, extracellular region, extracellular space
apoptotic process, cellular response to heat, cellular response to lipopolysaccharide, cellular sodium ion homeostasis, connective tissue replacement involved in inflammatory response wound healing, cytokine-mediated signaling pathway, ectopic germ cell programmed cell death, extrinsic apoptotic signaling pathway in absence of ligand, fever generation, immune response, inflammatory response, interleukin-1-mediated signaling pathway, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of angiogenesis, positive regulation of cell division, positive regulation of cytokine production, positive regulation of gene expression, positive regulation of immature T cell proliferation in thymus, positive regulation of interleukin-2 production, positive regulation of interleukin-6 production, positive regulation of mitotic nuclear division, positive regulation of protein secretion, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of vascular endothelial growth factor production, regulation of nitric-oxide synthase activity, response to copper ion
activation of MAPK activity, apoptotic process, cell-cell signaling, cellular response to drug, cellular response to lipopolysaccharide, cellular response to mechanical stimulus, cellular response to organic cyclic compound, cellular response to organic substance, cytokine-mediated signaling pathway, embryo implantation, fever generation, hyaluronan biosynthetic process, immune response, inflammatory response, interleukin-1-mediated signaling pathway, lipopolysaccharide-mediated signaling pathway, MAPK cascade, monocyte aggregation, negative regulation of adiponectin secretion, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of gap junction assembly, negative regulation of glucose transmembrane transport, negative regulation of insulin receptor signaling pathway, negative regulation of lipid catabolic process, negative regulation of lipid metabolic process, negative regulation of MAP kinase activity, negative regulation of neurogenesis, negative regulation of synaptic transmission, positive regulation of angiogenesis, positive regulation of calcidiol 1-monooxygenase activity, positive regulation of cell adhesion molecule production, positive regulation of cell division, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of complement activation, positive regulation of DNA-binding transcription factor activity, positive regulation of epithelial to mesenchymal transition, positive regulation of fever generation, positive regulation of gene expression, positive regulation of glial cell proliferation, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of heterotypic cell-cell adhesion, positive regulation of histone acetylation, positive regulation of histone phosphorylation, positive regulation of immature T cell proliferation in thymus, positive regulation of inflammatory response, positive regulation of interferon-gamma production, positive regulation of interleukin-2 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of JNK cascade, positive regulation of lipid catabolic process, positive regulation of membrane protein ectodomain proteolysis, positive regulation of mitotic nuclear division, positive regulation of monocyte chemotactic protein-1 production, positive regulation of myosin light chain kinase activity, positive regulation of neuroinflammatory response, positive regulation of NF-kappaB transcription factor activity, positive regulation of NIK/NF-kappaB signaling, positive regulation of nitric oxide biosynthetic process, positive regulation of p38MAPK cascade, positive regulation of phagocytosis, positive regulation of prostaglandin biosynthetic process, positive regulation of prostaglandin secretion, positive regulation of protein export from nucleus, positive regulation of protein phosphorylation, positive regulation of RNA biosynthetic process, positive regulation of T cell mediated immunity, positive regulation of T cell proliferation, positive regulation of T-helper 1 cell cytokine production, positive regulation of transcription, DNA-templated, positive regulation of vascular endothelial growth factor production, positive regulation of vascular endothelial growth factor receptor signaling pathway, protein kinase B signaling, purinergic nucleotide receptor signaling pathway, regulation of ERK1 and ERK2 cascade, regulation of establishment of endothelial barrier, regulation of I-kappaB kinase/NF-kappaB signaling, regulation of insulin secretion, regulation of neurogenesis, regulation of nitric-oxide synthase activity, response to interleukin-1, response to lipopolysaccharide, sequestering of triglyceride, signal transduction, smooth muscle adaptation, vascular endothelial growth factor production
