Details of family id : FD00189
| Family ID |
FD00189 |
| Protein Name |
Serine protease HTRA2 |
| UniProt ID |
O43464
Q9VFJ3
|
| Prosequence Length Range (aa) |
57-102
|
| Preproprotein Length Range(aa) |
422-458 |
| Preproprotein pI Range |
9.5-10.07 |
| Preproprotein Molecular Weight Range (D) |
45999.54-48840.85 |
| Prosequence pI Range (D) |
10.41-11.36 |
| Prosequence Molecular Weight Range |
6353.0-10435.86 |
| Domains |
cl37035 |
| Organisms |
Homo sapiens (Human); Drosophila melanogaster (Fruit fly) |
| Functions |
identical protein binding; peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; unfolded protein binding |
| Cellular Localization |
CD40 receptor complex; chromatin; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial intermembrane space; mitochondrial membrane; mitochondrion; nucleus; serine-type endopeptidase complex; integral component of membrane; Nebenkern |
| Processes |
adult walking behavior; aging; cellular protein catabolic process; cellular response to growth factor stimulus; cellular response to heat; cellular response to interferon-beta; cellular response to oxidative stress; cellular response to retinoic acid; ceramide metabolic process; execution phase of apoptosis; forebrain development; intrinsic apoptotic signaling pathway in response to DNA damage; mitochondrion organization; negative regulation of cell cycle; negative regulation of mitophagy in response to mitochondrial depolarization; negative regulation of neuron death; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; neuron development; pentacyclic triterpenoid metabolic process; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of mitochondrion organization; positive regulation of protein targeting to mitochondrion; programmed cell death; protein autoprocessing; proteolysis; regulation of autophagy of mitochondrion; regulation of multicellular organism growth; response to herbicide; apoptotic process; ectopic germ cell programmed cell death; positive regulation of cysteine-type endopeptidase activity; regulation of apoptotic process; spermatogenesis |
| Common Name |
serine protease |
