Details of family id : FD00092
| Family ID |
FD00092 |
| Protein Name |
Interleukin-1 beta ; Interleukin-1 beta; Interleukin-1 alpha |
| UniProt ID |
P01584
P10749
P01583
|
| Prosequence Length Range (aa) |
112-117
|
| Preproprotein Length Range(aa) |
269-271 |
| Preproprotein pI Range |
4.56-5.04 |
| Preproprotein Molecular Weight Range (D) |
30606.61-30931.06 |
| Prosequence pI Range (D) |
3.75-4.87 |
| Prosequence Molecular Weight Range |
12577.06-13555.18 |
| Domains |
pfam02394 : smart00125 |
| Organisms |
Homo sapiens (Human); Mus musculus (Mouse) |
| Functions |
cytokine activity; integrin binding; interleukin-1 receptor binding; protein domain specific binding; copper ion binding |
| Cellular Localization |
cytosol; extracellular region; extracellular space; lysosome; autophagosome; secretory granule; vesicle |
| Processes |
activation of MAPK activity; apoptotic process; cell-cell signaling; cellular response to drug; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to organic cyclic compound; cellular response to organic substance; cytokine-mediated signaling pathway; embryo implantation; fever generation; hyaluronan biosynthetic process; immune response; inflammatory response; interleukin-1-mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; MAPK cascade; monocyte aggregation; negative regulation of adiponectin secretion; negative regulation of cell population proliferation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of gap junction assembly; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of synaptic transmission; positive regulation of angiogenesis; positive regulation of calcidiol 1-monooxygenase activity; positive regulation of cell adhesion molecule production; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of complement activation; positive regulation of DNA-binding transcription factor activity; positive regulation of epithelial to mesenchymal transition; positive regulation of fever generation; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of heterotypic cell-cell adhesion; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of immature T cell proliferation in thymus; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of lipid catabolic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of mitotic nuclear division; positive regulation of monocyte chemotactic protein-1 production; positive regulation of myosin light chain kinase activity; positive regulation of neuroinflammatory response; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of p38MAPK cascade; positive regulation of phagocytosis; positive regulation of prostaglandin biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of protein export from nucleus; positive regulation of protein phosphorylation; positive regulation of RNA biosynthetic process; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell cytokine production; positive regulation of transcription; DNA-templated; positive regulation of vascular endothelial growth factor production; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein kinase B signaling; purinergic nucleotide receptor signaling pathway; regulation of ERK1 and ERK2 cascade; regulation of establishment of endothelial barrier; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of insulin secretion; regulation of neurogenesis; regulation of nitric-oxide synthase activity; response to interleukin-1; response to lipopolysaccharide; sequestering of triglyceride; signal transduction; smooth muscle adaptation; vascular endothelial growth factor production; astrocyte activation; ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; leukocyte migration; memory; negative regulation of branching morphogenesis of a nerve; negative regulation of gene expression; negative regulation of glutamate secretion; negative regulation of neural precursor cell proliferation; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; neutrophil chemotaxis; positive regulation of apoptotic process; positive regulation of astrocyte differentiation; positive regulation of cell death; positive regulation of chemokine production; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of glial cell differentiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JUN kinase activity; positive regulation of neuron apoptotic process; positive regulation of neutrophil chemotaxis; positive regulation of stress-activated MAPK cascade; positive regulation of transcription by RNA polymerase II; regulation of defense response to virus by host; response to ATP; response to carbohydrate; social behavior; cellular response to heat; cellular sodium ion homeostasis; connective tissue replacement involved in inflammatory response wound healing; positive regulation of cytokine production; positive regulation of protein secretion; positive regulation of tumor necrosis factor production; response to copper ion |
| Common Name |
Interleukin |
