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Details of PSQ00675

ProSeqID PSQ00675
Family FD00348
Protein Name Prothrombin
UniProt ID P00734
Taxonomy Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Primates-Haplorrhini-Catarrhini-Hominidae-Homo
Organisms Homo sapiens (Human)
Prosequence Length (aa) 19
Functions calcium ion binding, enzyme activator activity, growth factor activity, heparin binding, lipopolysaccharide binding, serine-type endopeptidase activity, signaling receptor binding, thrombospondin receptor activity
Preproprotein Length (aa) 622
Alt Name Coagulation factor II
Gene Name F2
NCBI ID 9606
Cellular Localization blood microparticle, collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, Golgi lumen, plasma membrane
Processes acute-phase response, antimicrobial humoral immune response mediated by antimicrobial peptide, blood coagulation, blood coagulation, intrinsic pathway, cell surface receptor signaling pathway, cellular protein metabolic process, cytolysis by host of symbiont cells, endoplasmic reticulum to Golgi vesicle-mediated transport, fibrinolysis, G protein-coupled receptor signaling pathway, leukocyte migration, multicellular organism development, negative regulation of astrocyte differentiation, negative regulation of cytokine production involved in inflammatory response, negative regulation of fibrinolysis, negative regulation of platelet activation, negative regulation of proteolysis, neutrophil-mediated killing of gram-negative bacterium, platelet activation, positive regulation of blood coagulation, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of collagen biosynthetic process, positive regulation of lipid kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of protein localization to nucleus, positive regulation of protein phosphorylation, positive regulation of reactive oxygen species metabolic process, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of release of sequestered calcium ion into cytosol, proteolysis, regulation of blood coagulation, regulation of cell shape, regulation of complement activation, regulation of cytosolic calcium ion concentration, response to wounding
PubMed 266717, 8073540
Total Prosequence Length (aa) 19
Prosequence Location 25:43
Prosequence Sequence QHVFLAPQQARSLLQRVRR
Preproprotein Sequence MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE