Details of family id : FD00348
| Family ID |
FD00348 |
| Protein Name |
Prothrombin |
| UniProt ID |
P00734
|
| Prosequence Length Range (aa) |
19
|
| Preproprotein Length Range(aa) |
622 |
| Preproprotein pI Range |
5.63 |
| Preproprotein Molecular Weight Range (D) |
70036.87 |
| Prosequence pI Range (D) |
12.48 |
| Prosequence Molecular Weight Range |
2303.7 |
| Domains |
cd00108 : cd00190 : pfam09396 : smart00069 : smart00130 |
| Organisms |
Homo sapiens (Human) |
| Functions |
calcium ion binding; enzyme activator activity; growth factor activity; heparin binding; lipopolysaccharide binding; serine-type endopeptidase activity; signaling receptor binding; thrombospondin receptor activity |
| Cellular Localization |
blood microparticle; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; Golgi lumen; plasma membrane |
| Processes |
acute-phase response; antimicrobial humoral immune response mediated by antimicrobial peptide; blood coagulation; intrinsic pathway; cell surface receptor signaling pathway; cellular protein metabolic process; cytolysis by host of symbiont cells; endoplasmic reticulum to Golgi vesicle-mediated transport; fibrinolysis; G protein-coupled receptor signaling pathway; leukocyte migration; multicellular organism development; negative regulation of astrocyte differentiation; negative regulation of cytokine production involved in inflammatory response; negative regulation of fibrinolysis; negative regulation of platelet activation; negative regulation of proteolysis; neutrophil-mediated killing of gram-negative bacterium; platelet activation; positive regulation of blood coagulation; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of collagen biosynthetic process; positive regulation of lipid kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of protein localization to nucleus; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of release of sequestered calcium ion into cytosol; proteolysis; regulation of blood coagulation; regulation of cell shape; regulation of complement activation; regulation of cytosolic calcium ion concentration; response to wounding |
| Common Name |
Prothrombin |
