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Prosequence Sequence

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Proseq ID Family Protein Name Uniprot ID Taxonomy Organism Prosequence length Functions Preproprotein length Alter Name Gene Name NCBI ID Cell Org Process PubMed Total Proseq length Proseq Loc Prosequence Sequence
PSQ00651 FD00298 Interleukin-33 O95760 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Homo sapiens (Human) 94 cytokine activity, interleukin-33 receptor binding 270 Interleukin-1 family member 11, Nuclear factor from high endothelial venules IL33 9606 chromosome, cytoplasm, extracellular region, extracellular space, intracellular membrane-bounded organelle, nucleoplasm, nucleus, transport vesicle defense response to virus, extrinsic apoptotic signaling pathway, interleukin-33-mediated signaling pathway, microglial cell activation involved in immune response, microglial cell proliferation, negative regulation of immunoglobulin production, negative regulation of interferon-gamma production, negative regulation of leukocyte migration, negative regulation of macrophage proliferation, negative regulation of T-helper 1 type immune response, negative regulation of transcription by RNA polymerase II, positive regulation of CD80 production, positive regulation of CD86 production, positive regulation of cellular defense response, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of gene expression, positive regulation of immunoglobulin production, positive regulation of inflammatory response, positive regulation of interleukin-13 production, positive regulation of interleukin-4 production, positive regulation of interleukin-5 production, positive regulation of interleukin-6 production, positive regulation of macrophage activation, positive regulation of MHC class I biosynthetic process, positive regulation of MHC class II biosynthetic process, positive regulation of neuroinflammatory response, positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type 2 immune response, protein deubiquitination 22307629 94 1:94 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECF
PSQ00652 FD00534 Apoptosis-inducing factor 1 O95831 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Homo sapiens (Human) 47 DNA binding, FAD binding, NAD(P)H oxidase H2O2-forming activity, NADH dehydrogenase activity, oxidoreductase activity, acting on NAD(P)H, protein dimerization activity 613 Programmed cell death protein 8 AIFM1 9606 cytosol, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, nucleus, perinuclear region of cytoplasm activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, chromosome condensation, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, mitochondrial respiratory chain complex assembly, mitochondrial respiratory chain complex I assembly, neuron differentiation, positive regulation of apoptotic process, protein import into mitochondrial intermembrane space 16365034 47 55:101 ASSGASGGKIDNSVLVLIVGLSTVGAGAYAYKTMKEDEKRYNERISG
PSQ00653 FD00031 Defensin O96049 Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Coleoptera Polyphaga Scarabaeiformia Scarabaeidae Dynastinae Oryctes Oryctes rhinoceros (Coconut rhinoceros beetle) 17 None 79 None None 72550 extracellular region defense response to bacterium, innate immune response 10561605 17 20:36 AAPAPEALEASVIRQKR
PSQ00654 FND00311 Antimicrobial peptide lumbricin-1 O96447 Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Haplotaxida Lumbricina Lumbricidae Lumbricinae Lumbricus Lumbricus rubellus (Humus earthworm) 14 None 76 None None 35632 None defense response to bacterium, defense response to fungus, killing of cells of other organism 9784609 14 1:14 MSLCISDYLYLTLT
PSQ00655 FD00490 Serine protease inhibitor dipetalogastin O96790 Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Triatominae Dipetalogaster Dipetalogaster maximus (Blood-sucking bug) 131 serine-type endopeptidase inhibitor activity 358 None None 72496 extracellular region negative regulation of coagulation 10702701 131 1:131 LIKELVNMVIQHAEEEEVKELKNPCECPRALHRVCGSDGNTYSNPCMLNCAKHEGNPDLVQVHKGPCDEHDHDFEDPCKCDNKFEPVCGDDQITYLNLCHLECATFTTSPGVEVAYEGECHAETTNAMEVL
PSQ00656 FD00222 Subtilisin-like protease 2 O97364 Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida Plasmodiidae Plasmodium Plasmodium (Laverania) Plasmodium falciparum 669 serine-type endopeptidase activity 1342 Merozoite surface sheddase , PfSUB2 SUB2 5833 cytoplasmic vesicle, integral component of membrane, microneme membrane, plasma membrane membrane protein ectodomain proteolysis 16322767 669 19:687 KECNNNNNYYLSNIELYNYKLRKRNRILNNNINDRKSFLSDLEQNYKPLFDIYELSANFEKRRKELEKKTKGEENEIEKKKENDLEEKKENEIEKKKENDLEKEYNDVINLLELSLSSEYKELNADVSNNDNSGHEENNKHKLNKKNSSNYKNDKSLDELIKGAILKLKQNPNIKNKNMLDYDKIFKIIKEKLINKNLASNKIKGGDNEKLKEEKKQSDISTNVEVKKDIINDQLNKGIPTKIENKDDMINKESNKEDITNEGKSNSLNNLNTLNNDGNIITKVYDHYTIVTNSNDILNDISIDASDISKNSIGGINIPFNENDNSSFTHQRYIVLSNNGEKKYKIVLMTKNPKFMDMDGIYDEEEKKESLIELNQKVNKEENTNLYDGTGTLYYGKKSKKEKENTQQKGGNNPNVDINILNNNNNNNNNNNNNSNNNSNSMNDEEINYNNNNNKESPSMFRRFINFLSFSGNENETEDTLIYHNKNDNSYKNKKEGTGKNNDNNDPNNNNNKKILLNVDKLVDQYLLNLKNNHTSKQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVENWSFSSTYHTYEADYIKEQDSVYDRSPKKKYIKASKKLYNNKYSFL
PSQ00657 FD00495 Enamelin O97939 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Suina Suidae Sus Sus scrofa (Pig) 238 None 1142 None ENAM 9823 extracellular region biomineral tissue development 9206327 238 277:514 NPRSNPTGQNGPAVNVSGQGVPRSQSPWGPRQTIIHENYPNPNIRGFPARRQWRPPGPAMGHRRNGPFYRNQQIQRGPRWNSFTLEGKQAVRPGYPTYRRVYGSTARSNPPNYAGNSANLRRKPEGPNKNPMVTNVAPPGPKHGTVDQNENIQNPREKQVSQKERTVVPTRDPSGPWRNSQDYGINKSNYKLPQPEDNMLVPNFNSIDQRENSYYPRGESKRAPNSDGQTQTQIIPKG
PSQ00658 FD00542 Cytochrome c oxidase subunit 2 P00410 Eukaryota Fungi Dikarya Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (strain ATCC 204508 15 copper ion binding, cytochrome-c oxidase activity 251 Cytochrome c oxidase polypeptide II COX2 559292 integral component of membrane, mitochondrial respiratory chain complex IV, mitochondrion aerobic respiration, ATP synthesis coupled electron transport, mitochondrial electron transport, cytochrome c to oxygen 1331058, 6313350, 7851399, 8879245 15 1:15 MLDLLRLQLTTFIMN
PSQ00659 FD00309 Amidophosphoribosyltransferase P00497 Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus subtilis (strain 168) 11 4 iron, 4 sulfur cluster binding, amidophosphoribosyltransferase activity, magnesium ion binding 480 Glutamine phosphoribosylpyrophosphate amidotransferase purF 224308 None , glutamine metabolic process, nucleoside metabolic process, purine nucleobase biosynthetic process, purine nucleotide biosynthetic process 6411716 11 1:11 MLAEIKGLNEE
PSQ00660 FD00029 Phospholipase A2 P00593 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos Bos taurus (Bovine) 7 bile acid binding, calcium ion binding, calcium-dependent phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), signaling receptor binding 145 Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B PLA2G1B 9913 cell surface, extracellular space antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, arachidonic acid secretion, defense response to Gram-positive bacterium, fatty acid biosynthetic process, innate immune response in mucosa, lipid catabolic process, phosphatidylcholine metabolic process, phosphatidylglycerol metabolic process, positive regulation of fibroblast proliferation, positive regulation of glomerular visceral epithelial cell apoptotic process 620674 7 16:22 QAGLNSR
PSQ00661 FD00010 Phospholipase A2 P00594 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Perissodactyla Equidae Equus Equus caballus (Horse) 7 bile acid binding, calcium ion binding, calcium-dependent phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), signaling receptor binding 132 Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B PLA2G1B 9796 extracellular region arachidonic acid secretion, fatty acid biosynthetic process, lipid catabolic process, phosphatidylglycerol metabolic process, positive regulation of fibroblast proliferation, positive regulation of glomerular visceral epithelial cell apoptotic process 838712 7 1:7 ENGISPR
PSQ00662 FD00010 Acidic phospholipase A2 CM-II P00596 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Elapinae Naja Naja kaouthia (Monocled cobra) (Naja siamensis) 6 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) 146 Acidic phospholipase A2 1, NnkPLA-I , Phosphatidylcholine 2-acylhydrolase None 8649 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 7460933 6 22:27 NRPMPL
PSQ00663 FD00010 Acidic phospholipase A2 2 P00597 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Elapinae Naja Naja kaouthia (Monocled cobra) (Naja siamensis) 6 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) 146 CM-III, NnkPLA-II, Phosphatidylcholine 2-acylhydrolase None 8649 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 7460933 6 22:27 NRPMPL
PSQ00664 FD00010 Acidic phospholipase A2 1 P00598 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Elapinae Naja Naja atra (Chinese cobra) 6 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), toxin activity 146 Muscarinic protein, Phosphatidylcholine 2-acylhydrolase None 8656 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 18281071, 7222082 6 22:27 NRPMPL
PSQ00665 FD00010 Acidic phospholipase A2 P00606 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Bungarinae Bungarus Bungarus multicinctus (Many-banded krait) 8 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) 145 Phosphatidylcholine 2-acylhydrolase None 8616 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 7217037 8 20:27 ANVPPQHL
PSQ00666 FD00010 Acidic phospholipase A2 1 P00611 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Laticaudinae Laticauda Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda, semifasciata) 6 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) 145 GL5-1, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 isozyme I None 8631 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 7165712 6 22:27 IPPLPL
PSQ00667 FD00010 Basic phospholipase A2 beta-bungarotoxin A1 chain P00617 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Bungarinae Bungarus Bungarus multicinctus (Many-banded krait) 8 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), toxin activity 147 Phosphatidylcholine 2-acylhydrolase None 8616 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 624701, 7096304 8 20:27 ANIPPHPL
PSQ00668 FD00010 Basic phospholipase A2 beta-bungarotoxin A2 chain P00618 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Bungarinae Bungarus Bungarus multicinctus (Many-banded krait) 8 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), toxin activity 145 Phosphatidylcholine 2-acylhydrolase None 8616 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 7096305 8 18:25 ANIPPHPL
PSQ00669 FD00010 Acidic phospholipase A2 beta-bungarotoxin A3 chain P00619 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Bungarinae Bungarus Bungarus multicinctus (Many-banded krait) 8 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), toxin activity 147 Phosphatidylcholine 2-acylhydrolase None 8616 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 7096305 8 20:27 ANIPPHPL
PSQ00670 FD00103 Phospholipase A2 P00630 Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Hymenoptera Apocrita Aculeata Apoidea Apidae Apis Apis mellifera (Honeybee) 15 calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) 167 Allergen Api m I, Phosphatidylcholine 2-acylhydrolase None 7460 extracellular region arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process 20403370, 4448181 15 19:33 WQIRDRIGDNELEER
PSQ00671 FD00586 Thermonuclease P00644 Bacteria Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus aureus 37, 19 endonuclease activity, metal ion binding, nucleic acid binding 238 Micrococcal nuclease, Staphylococcal nuclease nuc 1280 extracellular region, membrane None 893427;4324890 56 27:63, 64:82 ISNVSKGQYAKRFFFFATSCLVLTLVVVSSLSSSANA, SQTDNGVNRSGSEDPTVYS
PSQ00672 FD00145 Ribonuclease P00648 Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus amyloliquefaciens group Bacillus amyloliquefaciens (Bacillus velezensis) 13 endoribonuclease activity, RNA binding 157 Barnase, RNase Ba None 1390 extracellular region None 4553460 13 35:47 AKTETSSHKAHTE
PSQ00673 FD00145 Ribonuclease P00649 Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus intermedius 24 endoribonuclease activity, RNA binding 162 Binase, RNase Bi None 1400 extracellular region None 761620 24 30:53 ETPLTQTATNETATIQLTSDVHTL
PSQ00674 FD00194 Carboxypeptidase A1 P00730 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos Bos taurus (Bovine) 94 metallocarboxypeptidase activity, zinc ion binding 420 None CPA1 9913 extracellular region leukotriene metabolic process 5102489 94 17:110 KEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPGSPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSR
PSQ00675 FD00348 Prothrombin P00734 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Homo sapiens (Human) 19 calcium ion binding, enzyme activator activity, growth factor activity, heparin binding, lipopolysaccharide binding, serine-type endopeptidase activity, signaling receptor binding, thrombospondin receptor activity 622 Coagulation factor II F2 9606 blood microparticle, collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, Golgi lumen, plasma membrane acute-phase response, antimicrobial humoral immune response mediated by antimicrobial peptide, blood coagulation, blood coagulation, intrinsic pathway, cell surface receptor signaling pathway, cellular protein metabolic process, cytolysis by host of symbiont cells, endoplasmic reticulum to Golgi vesicle-mediated transport, fibrinolysis, G protein-coupled receptor signaling pathway, leukocyte migration, multicellular organism development, negative regulation of astrocyte differentiation, negative regulation of cytokine production involved in inflammatory response, negative regulation of fibrinolysis, negative regulation of platelet activation, negative regulation of proteolysis, neutrophil-mediated killing of gram-negative bacterium, platelet activation, positive regulation of blood coagulation, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of collagen biosynthetic process, positive regulation of lipid kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of protein localization to nucleus, positive regulation of protein phosphorylation, positive regulation of reactive oxygen species metabolic process, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of release of sequestered calcium ion into cytosol, proteolysis, regulation of blood coagulation, regulation of cell shape, regulation of complement activation, regulation of cytosolic calcium ion concentration, response to wounding 266717, 8073540 19 25:43 QHVFLAPQQARSLLQRVRR
PSQ00676 FD00017 Coagulation factor IX P00740 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Homo sapiens (Human) 18 calcium ion binding, endopeptidase activity, serine-type endopeptidase activity 461 Christmas factor, Plasma thromboplastin component F9 9606 collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, Golgi lumen, plasma membrane blood coagulation, blood coagulation, intrinsic pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, proteolysis, zymogen activation 2592373 18 29:46 TVFLDHENANKILNRPKR
PSQ00677 FD00017 Coagulation factor X P00742 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Homo sapiens (Human) 9 calcium ion binding, phospholipid binding, serine-type endopeptidase activity 488 Stuart factor, Stuart-Prower factor F10 9606 endoplasmic reticulum lumen, extracellular region, extracellular space, Golgi lumen, intrinsic component of external side of plasma membrane, plasma membrane blood coagulation, blood coagulation, extrinsic pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, negative regulation of blood coagulation, extrinsic pathway, positive regulation of cell migration, positive regulation of protein kinase B signaling 6871167 9 32:40 NNILARVTR
PSQ00678 FD00017 Coagulation factor X P00743 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos Bos taurus (Bovine) 17 calcium ion binding, serine-type endopeptidase activity 492 Stuart factor F10 9913 extracellular space blood coagulation 6766735 17 24:40 VFLPRDQAHRVLQRARR
PSQ00679 FD00017 Vitamin K-dependent protein C P00745 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos Bos taurus (Bovine) 24 calcium ion binding, serine-type endopeptidase activity 456 Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV PROC 9913 endoplasmic reticulum, extracellular space, Golgi apparatus blood coagulation, negative regulation of apoptotic process, negative regulation of blood coagulation, negative regulation of coagulation, negative regulation of inflammatory response, positive regulation of establishment of endothelial barrier 6896876 24 16:39 TPAPPDSVFSSSQRAHQVLRIRKR
PSQ00680 FD00300 Tissue-type plasminogen activator P00750 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Homo sapiens (Human) 10 phosphoprotein binding, serine-type endopeptidase activity, signaling receptor binding 562 None PLAT 9606 cell surface, cytoplasm, extracellular exosome, extracellular region, extracellular space blood coagulation, cellular protein modification process, fibrinolysis, negative regulation of proteolysis, plasminogen activation, platelet-derived growth factor receptor signaling pathway, prevention of polyspermy, proteolysis, smooth muscle cell migration 6682760 10 23:32 SQEIHARFRR
PSQ00681 FD00004 Kallikrein 1-related peptidase b3 P00756 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) 6 endopeptidase activity, growth factor activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding, serine-type endopeptidase activity 261 7S nerve growth factor gamma chain, Gamma-NGF, Glandular kallikrein K3, Tissue kallikrein-3 Klk1b3 10090 extracellular space, protein-containing complex, secretory granule regulation of systemic arterial blood pressure, zymogen activation 7263706 6 19:24 PPVQSR
PSQ00682 FD00007 Tonin P00759 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) 6 metal ion binding, serine-type endopeptidase activity, serine-type peptidase activity 259 Esterase 1, Glandular kallikrein-2, RSKG-5, S2 kallikrein Klk2 10116 secretory granule regulation of systemic arterial blood pressure, zymogen activation 1315752, 2302205, 3038148, 6320014 6 19:24 PPGQSR
PSQ00683 FD00004 Trypsin P00761 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Suina Suidae Sus Sus scrofa (Pig) 8 metal ion binding, serine-type endopeptidase activity 238 None None 9823 extracellular space digestion, proteolysis 4738933 8 1:8 FPTDDDDK
PSQ00684 FD00004 Trypsin P00764 Eukaryota Metazoa Chordata Craniata Vertebrata Chondrichthyes Elasmobranchii Squalomorphii Squaliformes Squalidae Squalus Squalus acanthias (Spiny dogfish) 7 metal ion binding, serine-type endopeptidase activity 229 None None 7797 extracellular space digestion 1092332 7 1:7 APDDDDK
PSQ00685 FD00004 Chymotrypsin-like elastase family member 1 P00772 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Suina Suidae Sus Sus scrofa (Pig) 10 metal ion binding, serine-type endopeptidase activity 266 Elastase-1 CELA1 9823 extracellular space proteolysis 4578945, 5415108 10 17:26 TQDFPETNAR
PSQ00686 FD00153 Streptogrisin-A P00776 Bacteria Actinobacteria Streptomycetales Streptomycetaceae Streptomyces Streptomyces griseus 77 serine-type endopeptidase activity 300 Pronase enzyme A, SGPA, Serine protease A sprA 1911 extracellular region None 4214713 77 39:115 APEAESKATVSQLADASSAILAADVAGTAWYTEASTGKIVLTADSTVSKAELAKVSNALAGSKAKLTVKRAEGKFTP
PSQ00687 FD00153 Streptogrisin-B P00777 Bacteria Actinobacteria Streptomycetales Streptomycetaceae Streptomyces Streptomyces griseus 76 serine-type endopeptidase activity 300 Pronase enzyme B, SGPB, Serine protease B sprB 1911 extracellular region None 4218101 76 39:114 ETPRTFSANQLTAASDAVLGADIAGTAWNIDPQSKRLVVTVDSTVSKAEINQIKKSAGANADALRIERTPGKFTKL
PSQ00688 FD00336 Subtilisin Carlsberg P00780 Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus licheniformis 76 metal ion binding, serine-type endopeptidase activity 379 None subC 1402 extracellular region None 4967581 76 30:105 AQPAKNVEKDYIVGFKSGVKTASVKKDIIKESGGKVDKQFRIINAAKAKLDKEALKEVKNDPDVAYVEEDHVAHAL
PSQ00689 FD00053 Subtilisin BPN P00782 Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus amyloliquefaciens group Bacillus amyloliquefaciens (Bacillus velezensis) 77 metal ion binding, serine-type endopeptidase activity 382 Alkaline protease, Subtilisin DFE, Subtilisin Novo apr 1390 extracellular region fibrinolysis, proteolysis, sporulation resulting in formation of a cellular spore 12524032, 6065094 77 31:107 AGKSNGEKKYIVGFKQTMSTMSAAKKKDVISEKGGKVQKQFKYVDAASATLNEKAVKELKKDPSVAYVEEDHVAHAY
PSQ00690 FD00053 Subtilisin amylosacchariticus P00783 Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus subtilis subsp 77 metal ion binding, serine-type endopeptidase activity 381 None apr 1483 extracellular region sporulation resulting in formation of a cellular spore 5055784 77 30:106 AGKSSTEKKYIVGFKQTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHIAHEY
PSQ00691 FD00012 Papain P00784 Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Caricaceae Carica Carica papaya (Papaya) 115 cysteine-type peptidase activity, serpin family protein binding 345 Papaya proteinase I None 3649 None None 5470818 115 19:133 VYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVN
PSQ00692 FD00012 Actinidain P00785 Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids Ericales Actinidiaceae Actinidia Actinidia chinensis var 102 cysteine-type endopeptidase activity 380 None ACT1A 1590841 None None 18442249, 687380 102 25:126 FNAKNLTQRTNDEVKAMYESWLIKYGKSYNSLGEWERRFEIFKETLRFIDEHNADTNRSYKVGLNQFADLTDEEFRSTYLGFTSGSNKTKVSNQYEPRVGQV
PSQ00693 FD00082 Cathepsin B P00787 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) 62 collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, endopeptidase activity, kininogen binding, peptidase activity, peptide binding, protein self-association, protein-containing complex binding, proteoglycan binding 339 Cathepsin B1, RSG-2 Ctsb 10116 apical plasma membrane, cell surface, cytoplasm, external side of plasma membrane, extracellular region, extracellular space, lysosome, melanosome, mitochondrion, perinuclear region of cytoplasm, sarcolemma autophagy, cellular response to mechanical stimulus, cellular response to thyroid hormone stimulus, collagen catabolic process, decidualization, epithelial cell differentiation, negative regulation of cell death, proteolysis, proteolysis involved in cellular protein catabolic process, regulation of catalytic activity, response to amine, response to cytokine, response to ethanol, response to glucose, response to interleukin-4, response to mechanical stimulus, response to organic cyclic compound, response to peptide hormone, response to wounding, skeletal muscle tissue development, spermatogenesis, thyroid hormone generation, viral entry into host cell 1639824, 6574504 62 18:79 HDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDIN
PSQ00694 FD00071 Pepsin A P00791 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Suina Suidae Sus Sus scrofa (Pig) 44 aspartic-type endopeptidase activity 385 None PGA 9823 extracellular region digestion 2494172, 4604255 44 16:59 LVKVPLVRKKSLRQNLIKNGKLKDFLKTHKHNPASKYFPEAAAL
PSQ00695 FD00071 Chymosin P00794 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos Bos taurus (Bovine) 42 aspartic-type endopeptidase activity 381 Preprorennin CYM 9913 None digestion 381305 42 17:58 AEITRIPLYKGKSLRKALKEHGLLEDFLQKQQYGISSKYSGF
PSQ00696 FD00099 Renin-2 P00796 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) 38 aspartic-type endopeptidase activity, endopeptidase activity 401 Angiotensinogenase, Submandibular gland renin Ren2 10090 extracellular space angiotensin maturation, positive regulation of blood pressure 6812055 38 26:63 TTFERIPLKKMPSVREILEERGVDMTRLSAEWDVFTKR
PSQ00697 FD00099 Renin P00797 Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Homo sapiens (Human) 43 aspartic-type endopeptidase activity, insulin-like growth factor receptor binding, peptidase activity, signaling receptor binding 406 Angiotensinogenase REN 9606 apical part of cell, cytoplasm, extracellular region, extracellular space, plasma membrane amyloid-beta metabolic process, angiotensin maturation, cell maturation, cellular response to drug, drinking behavior, hormone-mediated signaling pathway, kidney development, male gonad development, mesonephros development, proteolysis, regulation of blood pressure, regulation of MAPK cascade, renin-angiotensin regulation of aldosterone production, response to cAMP, response to cGMP, response to immobilization stress, response to lipopolysaccharide 2016271 43 24:66 LPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKR
PSQ00698 FD00049 Thermolysin P00800 Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus thermoproteolyticus 204 metal ion binding, metalloendopeptidase activity 548 Thermostable neutral proteinase npr 1427 extracellular region None 5040648 204 29:232 STEHVTWNQQFQTPQFISGDLLKVNGTSPEELVYQYVEKNENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTSHVKDGTLTALSGTLIPNLDTKGSLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVYVNGDEASLAYVVNLNFLTPEPGNWLYIIDAVDGKILNKFNQLDAAKPGDVKS
PSQ00699 FD00122 ATP synthase subunit a P00854 Eukaryota Fungi Dikarya Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (strain ATCC 204508 10 proton transmembrane transporter activity 259 F-ATPase protein 6 ATP6 559292 integral component of membrane, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion ATP synthesis coupled proton transport 2894987 10 1:10 MFNLLNTYIT
PSQ00700 FD00110 Bowman-Birk type proteinase inhibitor P01055 Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Fabales Fabaceae Papilionoideae 50 kb inversion clade NPAAA clade indigoferoid/millettioid clade Phaseoleae Glycine Glycine subgen Soja Glycine max (Soybean) (Glycine hispida) 20 serine-type endopeptidase inhibitor activity 110 None None 3847 extracellular region None 4672481 20 20:39 ANLRLSKLGLLMKSDHQHSN
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