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Details of PSQ00693

ProSeqID PSQ00693
Family FD00082
Protein Name Cathepsin B
UniProt ID P00787
Taxonomy Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Glires-Rodentia-Myomorpha-Muroidea-Muridae-Murinae-Rattus
Organisms Rattus norvegicus (Rat)
Prosequence Length (aa) 62
Functions collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, endopeptidase activity, kininogen binding, peptidase activity, peptide binding, protein self-association, protein-containing complex binding, proteoglycan binding
Preproprotein Length (aa) 339
Alt Name Cathepsin B1, RSG-2
Gene Name Ctsb
NCBI ID 10116
Cellular Localization apical plasma membrane, cell surface, cytoplasm, external side of plasma membrane, extracellular region, extracellular space, lysosome, melanosome, mitochondrion, perinuclear region of cytoplasm, sarcolemma
Processes autophagy, cellular response to mechanical stimulus, cellular response to thyroid hormone stimulus, collagen catabolic process, decidualization, epithelial cell differentiation, negative regulation of cell death, proteolysis, proteolysis involved in cellular protein catabolic process, regulation of catalytic activity, response to amine, response to cytokine, response to ethanol, response to glucose, response to interleukin-4, response to mechanical stimulus, response to organic cyclic compound, response to peptide hormone, response to wounding, skeletal muscle tissue development, spermatogenesis, thyroid hormone generation, viral entry into host cell
PubMed 1639824, 6574504
Total Prosequence Length (aa) 62
Prosequence Location 18:79
Prosequence Sequence HDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDIN
Preproprotein Sequence MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF