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Details of PSQ02060

ProSeqID PSQ02060
Family FD00420
Protein Name Appetite-regulating hormone
UniProt ID Q9QYH7
Taxonomy Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Glires-Rodentia-Myomorpha-Muroidea-Muridae-Murinae-Rattus
Organisms Rattus norvegicus (Rat)
Prosequence Length (aa) 24
Functions G protein-coupled receptor binding, ghrelin receptor binding, growth hormone-releasing hormone activity, hormone activity, protein tyrosine kinase activator activity
Preproprotein Length (aa) 120
Alt Name Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide
Gene Name Ghrl
NCBI ID 10116
Cellular Localization axon, cytoplasm, extracellular region, extracellular space, glutamatergic synapse, postsynapse, Schaffer collateral - CA1 synapse
Processes actin polymerization or depolymerization, activation of MAPK activity, adult feeding behavior, decidualization, dendrite development, energy homeostasis, excitatory postsynaptic potential, G protein-coupled receptor signaling pathway, gastric acid secretion, gastric emptying, negative regulation of apoptotic process, negative regulation of circadian sleep/wake cycle, REM sleep, negative regulation of endothelial cell proliferation, negative regulation of inflammatory response, negative regulation of insulin secretion, negative regulation of interleukin-1 beta production, negative regulation of interleukin-6 production, negative regulation of locomotion, negative regulation of tumor necrosis factor production, positive regulation of adipose tissue development, positive regulation of appetite, positive regulation of bone development, positive regulation of circadian sleep/wake cycle, non-REM sleep, positive regulation of cold-induced thermogenesis, positive regulation of corticotropin secretion, positive regulation of cortisol secretion, positive regulation of cytosolic calcium ion concentration, positive regulation of eating behavior, positive regulation of feeding behavior, positive regulation of gastric mucosal blood circulation, positive regulation of gastro-intestinal system smooth muscle contraction, positive regulation of growth, positive regulation of growth hormone secretion, positive regulation of growth rate, positive regulation of insulin secretion, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of response to food, positive regulation of small intestinal transit, positive regulation of small intestine smooth muscle contraction, positive regulation of sprouting angiogenesis, positive regulation of synapse assembly, positive regulation of vascular endothelial cell proliferation, postsynaptic modulation of chemical synaptic transmission, regulation of cell population proliferation, regulation of gastric motility, regulation of postsynapse organization, regulation of response to food, regulation of transmission of nerve impulse, response to electrical stimulus, response to estrogen, response to hormone, response to nutrient levels
PubMed 16284174
Total Prosequence Length (aa) 24
Prosequence Location 52:75
Prosequence Sequence ALEGWLHPEDRGQAEEAEEELEIR
Preproprotein Sequence MVSSATICSLLLLSMLWMDMAMAGSSFLSPEHQKAQQRKESKKPPAKLQPRALEGWLHPEDRGQAEEAEEELEIRFNAPFDVGIKLSGAQYQQHGRALGKFLQDILWEEVKEAPANKn/