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Details of PSQ02001

ProSeqID PSQ02001
Family FD00195
Protein Name Forkhead box protein P3
UniProt ID Q99JB6
Taxonomy Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Glires-Rodentia-Myomorpha-Muroidea-Muridae-Murinae-Mus-Mus
Organisms Mus musculus (Mouse)
Prosequence Length (aa) 12
Functions DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, histone acetyltransferase binding, histone deacetylase binding, identical protein binding, metal ion binding, NFAT protein binding, protein homodimerization activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor activity
Preproprotein Length (aa) 429
Alt Name Scurfin
Gene Name Foxp3
NCBI ID 10090
Cellular Localization cytoplasm, nucleoplasm, nucleus
Processes B cell homeostasis, CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment, gene expression, myeloid cell homeostasis, negative regulation of cell population proliferation, negative regulation of chronic inflammatory response, negative regulation of CREB transcription factor activity, negative regulation of cytokine production, negative regulation of defense response to virus, negative regulation of DNA-binding transcription factor activity, negative regulation of gene expression, negative regulation of histone acetylation, negative regulation of histone deacetylation, negative regulation of immune response, negative regulation of inflammatory response, negative regulation of interferon-gamma production, negative regulation of interleukin-10 production, negative regulation of interleukin-17 production, negative regulation of interleukin-2 production, negative regulation of interleukin-4 production, negative regulation of interleukin-5 production, negative regulation of interleukin-6 production, negative regulation of isotype switching to IgE isotypes, negative regulation of lymphocyte proliferation, negative regulation of NF-kappaB transcription factor activity, negative regulation of T cell cytokine production, negative regulation of T cell proliferation, negative regulation of T-helper 17 cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, negative regulation of tumor necrosis factor production, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, positive regulation of gene expression, positive regulation of histone acetylation, positive regulation of immature T cell proliferation in thymus, positive regulation of interleukin-4 production, positive regulation of peripheral T cell tolerance induction, positive regulation of regulatory T cell differentiation, positive regulation of T cell anergy, positive regulation of T cell tolerance induction, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, positive regulation of transforming growth factor beta1 production, regulation of immunoglobulin production, regulation of isotype switching to IgG isotypes, regulation of T cell anergy, regulation of transcription by RNA polymerase II, response to lipopolysaccharide, response to virus, T cell activation, T cell mediated immunity, T cell receptor signaling pathway, tolerance induction, tolerance induction to self antigen
PubMed 19117830
Total Prosequence Length (aa) 12
Prosequence Location 418:429
Prosequence Sequence SQRPNKCSNPCP
Preproprotein Sequence MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDLRSGAHTSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHAQTPVLQVRPLDNPAMISLPPPSAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREAPDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPNKCSNPCP