Details of PSQ01654
| ProSeqID |
PSQ01654 |
| Family |
FD00208 |
| Protein Name |
Caspase-8 |
| UniProt ID |
Q14790
|
| Taxonomy |
Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Primates-Haplorrhini-Catarrhini-Hominidae-Homo |
| Organisms |
Homo sapiens (Human) |
| Prosequence Length (aa) |
216, 10 |
| Functions |
cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity, death effector domain binding, death receptor binding, identical protein binding, peptidase activity, protein-containing complex binding, scaffold protein binding, tumor necrosis factor receptor binding, ubiquitin protein ligase binding |
| Preproprotein Length (aa) |
480 |
| Alt Name |
Apoptotic cysteine protease, Apoptotic protease Mch-5 , CAP4, FADD-homologous ICE, FADD-like ICE , ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog |
| Gene Name |
CASP8 |
| NCBI ID |
9606 |
| Cellular Localization |
CD95 death-inducing signaling complex, cell body, cytoplasm, cytoskeleton, cytosol, death-inducing signaling complex, membrane raft, mitochondrial outer membrane, mitochondrion, neuron projection, nucleoplasm, protein-containing complex, ripoptosome |
| Processes |
activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, angiogenesis, apoptotic process, apoptotic signaling pathway, B cell activation, cell surface receptor signaling pathway, cellular response to mechanical stimulus, cellular response to organic cyclic compound, death-inducing signaling complex assembly, execution phase of apoptosis, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, heart development, macrophage differentiation, modulation by virus of host cellular process, natural killer cell activation, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of necroptotic process, nucleotide-binding oligomerization domain containing signaling pathway, positive regulation of apoptotic process, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-1 beta production, positive regulation of macrophage differentiation, positive regulation of neuron death, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, positive regulation of proteolysis, proteolysis, proteolysis involved in cellular protein catabolic process, pyroptosis, regulation of cytokine production, regulation of extrinsic apoptotic signaling pathway via death domain receptors, regulation of innate immune response, regulation of necroptotic process, regulation of tumor necrosis factor-mediated signaling pathway, response to antibiotic, response to cobalt ion, response to cold, response to estradiol, response to ethanol, response to lipopolysaccharide, response to tumor necrosis factor, self proteolysis, suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process, syncytiotrophoblast cell differentiation involved in labyrinthine layer development, T cell activation, toll-like receptor 3 signaling pathway, TRAIL-activated apoptotic signaling pathway, TRIF-dependent toll-like receptor signaling pathway |
| PubMed |
8962078,
9184224,8962078,
9184224
|
| Total Prosequence Length (aa) |
226 |
| Prosequence Location |
1:216, 375:384 |
| Prosequence Sequence |
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQD, SEEQPYLEMD |
| Preproprotein Sequence |
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD |
