Details of family id : FD00208
| Family ID |
FD00208 |
| Protein Name |
Caspase-8 |
| UniProt ID |
Q14790
O89110
|
| Prosequence Length Range (aa) |
10-218
|
| Preproprotein Length Range(aa) |
480 |
| Preproprotein pI Range |
4.99-5.12 |
| Preproprotein Molecular Weight Range (D) |
55356.88-55391.11 |
| Prosequence pI Range (D) |
3.5-4.74 |
| Prosequence Molecular Weight Range |
1240.3-25596.4 |
| Domains |
cd00032 : cd08333 : cl14633 |
| Organisms |
Homo sapiens (Human); Mus musculus (Mouse) |
| Functions |
cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; death effector domain binding; death receptor binding; identical protein binding; peptidase activity; protein-containing complex binding; scaffold protein binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; endopeptidase activity |
| Cellular Localization |
CD95 death-inducing signaling complex; cell body; cytoplasm; cytoskeleton; cytosol; death-inducing signaling complex; membrane raft; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; protein-containing complex; ripoptosome; Noc1p-Noc2p complex; nucleus; plasma membrane |
| Processes |
activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; angiogenesis; apoptotic process; apoptotic signaling pathway; B cell activation; cell surface receptor signaling pathway; cellular response to mechanical stimulus; cellular response to organic cyclic compound; death-inducing signaling complex assembly; execution phase of apoptosis; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; heart development; macrophage differentiation; modulation by virus of host cellular process; natural killer cell activation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of necroptotic process; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; positive regulation of macrophage differentiation; positive regulation of neuron death; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; proteolysis; proteolysis involved in cellular protein catabolic process; pyroptosis; regulation of cytokine production; regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of innate immune response; regulation of necroptotic process; regulation of tumor necrosis factor-mediated signaling pathway; response to antibiotic; response to cobalt ion; response to cold; response to estradiol; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; self proteolysis; suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; syncytiotrophoblast cell differentiation involved in labyrinthine layer development; T cell activation; toll-like receptor 3 signaling pathway; TRAIL-activated apoptotic signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cardiac muscle tissue development; hepatocyte apoptotic process; neural tube formation; positive regulation of extrinsic apoptotic signaling pathway; protein processing; regulation of apoptotic signaling pathway; regulation of thymocyte apoptotic process |
| Common Name |
Caspase |
