Details of PSQ00645
| ProSeqID |
PSQ00645 |
| Family |
FD00208 |
| Protein Name |
Caspase-8 |
| UniProt ID |
O89110
|
| Taxonomy |
Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Glires-Rodentia-Myomorpha-Muroidea-Muridae-Murinae-Mus-Mus |
| Organisms |
Mus musculus (Mouse) |
| Prosequence Length (aa) |
218, 11 |
| Functions |
cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, death effector domain binding, death receptor binding, endopeptidase activity, identical protein binding, peptidase activity, protein-containing complex binding, scaffold protein binding, tumor necrosis factor receptor binding, ubiquitin protein ligase binding |
| Preproprotein Length (aa) |
480 |
| Alt Name |
None |
| Gene Name |
Casp8 |
| NCBI ID |
10090 |
| Cellular Localization |
CD95 death-inducing signaling complex, cell body, cytoplasm, cytosol, death-inducing signaling complex, membrane raft, mitochondrion, neuron projection, Noc1p-Noc2p complex, nucleoplasm, nucleus, plasma membrane, protein-containing complex, ripoptosome |
| Processes |
activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, angiogenesis, apoptotic process, apoptotic signaling pathway, cardiac muscle tissue development, execution phase of apoptosis, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, heart development, hepatocyte apoptotic process, macrophage differentiation, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of necroptotic process, neural tube formation, positive regulation of apoptotic process, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-1 beta production, positive regulation of macrophage differentiation, positive regulation of neuron death, positive regulation of proteolysis, protein processing, proteolysis, proteolysis involved in cellular protein catabolic process, pyroptosis, regulation of apoptotic signaling pathway, regulation of cytokine production, regulation of innate immune response, regulation of thymocyte apoptotic process, response to ethanol, response to tumor necrosis factor, self proteolysis, TRAIL-activated apoptotic signaling pathway |
| PubMed |
3151169231511692
|
| Total Prosequence Length (aa) |
229 |
| Prosequence Location |
1:218, 377:387 |
| Prosequence Sequence |
MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQD, FEQQNHTLEVD |
| Preproprotein Sequence |
MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP |
