Details of family id : FD00454
| Family ID |
FD00454 |
| Protein Name |
Endothelin-1 |
| UniProt ID |
P22388
|
| Prosequence Length Range (aa) |
25
|
| Preproprotein Length Range(aa) |
202 |
| Preproprotein pI Range |
9.77 |
| Preproprotein Molecular Weight Range (D) |
23134.93 |
| Prosequence pI Range (D) |
10.67 |
| Prosequence Molecular Weight Range |
2849.16 |
| Domains |
pfam00322 |
| Organisms |
Rattus norvegicus (Rat) |
| Functions |
cytokine activity; endothelin A receptor binding; endothelin B receptor binding; hormone activity; signaling receptor binding |
| Cellular Localization |
basal part of cell; cytoplasm; extracellular space; rough endoplasmic reticulum lumen; Weibel-Palade body |
| Processes |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; artery smooth muscle contraction; blood vessel morphogenesis; body fluid secretion; branching involved in blood vessel morphogenesis; calcium-mediated signaling; cartilage development; cell surface receptor signaling pathway; cell-cell signaling; cellular calcium ion homeostasis; cellular response to calcium ion; cellular response to drug; cellular response to fatty acid; cellular response to glucocorticoid stimulus; cellular response to hypoxia; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to mineralocorticoid stimulus; cellular response to peptide hormone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; dorsal/ventral pattern formation; endothelin receptor signaling pathway; epithelial fluid transport; G protein-coupled receptor signaling pathway; heart development; histamine secretion; in utero embryonic development; inositol phosphate-mediated signaling; intracellular signal transduction; maternal process involved in parturition; membrane depolarization; middle ear morphogenesis; multicellular organism aging; negative regulation of cellular protein metabolic process; negative regulation of gene expression; negative regulation of hormone secretion; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of smooth muscle cell apoptotic process; negative regulation of transcription by RNA polymerase II; neural crest cell development; nitric oxide transport; peptide hormone secretion; phosphatidylinositol 3-kinase signaling; phospholipase D-activating G protein-coupled receptor signaling pathway; positive regulation of cardiac muscle hypertrophy; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell size; positive regulation of chemokine-mediated signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of DNA-binding transcription factor activity; positive regulation of heart rate; positive regulation of hormone secretion; positive regulation of JUN kinase activity; positive regulation of MAP kinase activity; positive regulation of mitotic nuclear division; positive regulation of neutrophil chemotaxis; positive regulation of NIK/NF-kappaB signaling; positive regulation of odontogenesis; positive regulation of prostaglandin secretion; positive regulation of prostaglandin-endoperoxide synthase activity; positive regulation of renal sodium excretion; positive regulation of sarcomere organization; positive regulation of signaling receptor activity; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of transcription by RNA polymerase II; positive regulation of urine volume; positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin biosynthetic process; protein kinase C deactivation; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of blood pressure; regulation of glucose transmembrane transport; regulation of pH; regulation of sensory perception of pain; regulation of systemic arterial blood pressure by endothelin; regulation of vasoconstriction; respiratory gaseous exchange by respiratory system; response to activity; response to amino acid; response to dexamethasone; response to drug; response to hypoxia; response to leptin; response to lipopolysaccharide; response to muscle stretch; response to nicotine; response to ozone; response to prostaglandin F; response to salt; response to testosterone; response to transforming growth factor beta; rhythmic excitation; sensory perception of pain; skeletal system development; superoxide anion generation; vasoconstriction; vein smooth muscle contraction |
| Common Name |
Endothelin |
