Details of family id : FD00258
| Family ID |
FD00258 |
| Protein Name |
Major prion protein |
| UniProt ID |
P04273
|
| Prosequence Length Range (aa) |
23
|
| Preproprotein Length Range(aa) |
254 |
| Preproprotein pI Range |
9.4 |
| Preproprotein Molecular Weight Range (D) |
27919.39 |
| Prosequence pI Range (D) |
5.24 |
| Prosequence Molecular Weight Range |
2464.09 |
| Domains |
pfam11587 : smart00157 |
| Organisms |
Mesocricetus auratus (Golden hamster) |
| Functions |
amyloid-beta binding; aspartic-type endopeptidase inhibitor activity; copper ion binding; cupric ion binding; glycosaminoglycan binding; identical protein binding; protease binding; protein-containing complex binding; signaling receptor activity; type 5 metabotropic glutamate receptor binding |
| Cellular Localization |
anchored component of membrane; cell surface; cytosol; dendrite; endoplasmic reticulum; Golgi apparatus; membrane raft; nuclear membrane; plasma membrane; terminal bouton |
| Processes |
activation of protein kinase activity; calcium-mediated signaling using intracellular calcium source; cell cycle arrest; cellular response to amyloid-beta; cellular response to drug; learning or memory; modulation of age-related behavioral decline; negative regulation of activated T cell proliferation; negative regulation of amyloid-beta formation; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of dendritic spine maintenance; negative regulation of DNA-binding transcription factor activity; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 production; negative regulation of protein phosphorylation; negative regulation of T cell receptor signaling pathway; neuron projection maintenance; positive regulation of neuron death; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein localization to plasma membrane; positive regulation of protein targeting to membrane; protein homooligomerization; regulation of calcium ion import across plasma membrane; regulation of glutamate receptor signaling pathway; regulation of potassium ion transmembrane transport; response to oxidative stress |
| Common Name |
major prion protein |
