Details of family id : FD00227
| Family ID |
FD00227 |
| Protein Name |
Proprotein convertase subtilisin |
| UniProt ID |
Q8NBP7
|
| Prosequence Length Range (aa) |
122
|
| Preproprotein Length Range(aa) |
692 |
| Preproprotein pI Range |
6.14 |
| Preproprotein Molecular Weight Range (D) |
74286.21 |
| Prosequence pI Range (D) |
5.04 |
| Prosequence Molecular Weight Range |
13772.49 |
| Domains |
cd04077 : cd16839 : pfam05922 |
| Organisms |
Homo sapiens (Human) |
| Functions |
apolipoprotein binding; apolipoprotein receptor binding; low-density lipoprotein particle binding; low-density lipoprotein particle receptor binding; protein self-association; receptor inhibitor activity; RNA binding; serine-type endopeptidase activity; sodium channel inhibitor activity; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle receptor binding |
| Cellular Localization |
cell surface; COPII-coated ER to Golgi transport vesicle; cytoplasm; early endosome; endolysosome membrane; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; extracellular space; extrinsic component of external side of plasma membrane; Golgi apparatus; late endosome; lysosomal membrane; lysosome; PCSK9-AnxA2 complex; PCSK9-LDLR complex; perinuclear region of cytoplasm; plasma membrane; rough endoplasmic reticulum |
| Processes |
apoptotic process; cellular protein metabolic process; cellular response to insulin stimulus; cellular response to starvation; cholesterol homeostasis; cholesterol metabolic process; kidney development; lipoprotein metabolic process; liver development; low-density lipoprotein particle clearance; low-density lipoprotein particle receptor catabolic process; lysosomal transport; negative regulation of low-density lipoprotein particle clearance; negative regulation of low-density lipoprotein particle receptor binding; negative regulation of low-density lipoprotein receptor activity; negative regulation of receptor recycling; negative regulation of receptor-mediated endocytosis involved in cholesterol transport; negative regulation of sodium ion transmembrane transporter activity; neurogenesis; neuron differentiation; phospholipid metabolic process; positive regulation of low-density lipoprotein particle receptor catabolic process; positive regulation of neuron apoptotic process; positive regulation of receptor internalization; post-translational protein modification; protein autoprocessing; regulation of neuron apoptotic process; regulation of signaling receptor activity; triglyceride metabolic process |
| Common Name |
Proprotein convertase subtilsin |
