Details of family id : FD00225
| Family ID |
FD00225 |
| Protein Name |
Sortilin-related receptor |
| UniProt ID |
Q92673
|
| Prosequence Length Range (aa) |
53
|
| Preproprotein Length Range(aa) |
2220 |
| Preproprotein pI Range |
5.32 |
| Preproprotein Molecular Weight Range (D) |
248426.37 |
| Prosequence pI Range (D) |
11.42 |
| Prosequence Molecular Weight Range |
6062.86 |
| Domains |
cd00063 : cd00063 : cd00063 : cd00112 : cd00112 : cd00112 : cd00112 : cd00112 : cd00112 : cd00112 : pfam00057 : pfam00058 : smart00135 : smart00135 : smart00192 : smart00192 : smart00602 |
| Organisms |
Homo sapiens (Human) |
| Functions |
amyloid-beta binding; low-density lipoprotein particle binding; low-density lipoprotein particle receptor activity; neuropeptide binding; small GTPase binding; transmembrane signaling receptor activity |
| Cellular Localization |
cell surface; early endosome; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular exosome; extracellular space; Golgi apparatus; Golgi cisterna; Golgi membrane; integral component of membrane; integral component of plasma membrane; membrane; multivesicular body; multivesicular body membrane; nuclear envelope lumen; perinucleolar compartment; plasma membrane; recycling endosome; recycling endosome membrane; trans-Golgi network; transport vesicle membrane |
| Processes |
adaptive thermogenesis; amyloid fibril formation; diet induced thermogenesis; insulin receptor recycling; negative regulation of amyloid-beta formation; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; negative regulation of BMP signaling pathway; negative regulation of MAP kinase activity; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; negative regulation of neurofibrillary tangle assembly; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of protein binding; negative regulation of protein-containing complex assembly; negative regulation of tau-protein kinase activity; negative regulation of triglyceride catabolic process; neuropeptide signaling pathway; positive regulation of adipose tissue development; positive regulation of choline O-acetyltransferase activity; positive regulation of early endosome to recycling endosome transport; positive regulation of endocytic recycling; positive regulation of ER to Golgi vesicle-mediated transport; positive regulation of glial cell-derived neurotrophic factor production; positive regulation of insulin receptor signaling pathway; positive regulation of protein catabolic process; positive regulation of protein exit from endoplasmic reticulum; positive regulation of protein localization to early endosome; post-Golgi vesicle-mediated transport; protein localization to Golgi apparatus; protein maturation; protein retention in Golgi apparatus; protein targeting; protein targeting to lysosome; receptor-mediated endocytosis; regulation of smooth muscle cell migration |
| Common Name |
sortilin related receptor |
