Details of family id : FD00125
| Family ID |
FD00125 |
| Protein Name |
Brain-derived neurotrophic factor; Brain-derived neurotrophic factor |
| UniProt ID |
P23560
P21237
|
| Prosequence Length Range (aa) |
110-112
|
| Preproprotein Length Range(aa) |
247-249 |
| Preproprotein pI Range |
8.91-9.01 |
| Preproprotein Molecular Weight Range (D) |
27817.94-28123.23 |
| Prosequence pI Range (D) |
5.16-5.3 |
| Prosequence Molecular Weight Range |
12272.83-12578.12 |
| Domains |
smart00140 |
| Organisms |
Homo sapiens (Human); Mus musculus (Mouse) |
| Functions |
growth factor activity; nerve growth factor receptor binding; neurotrophin TRKB receptor binding |
| Cellular Localization |
axon; cytoplasm; dendrite; extracellular region; extracellular space; mitochondrion; nuclear speck; perinuclear region of cytoplasm; synaptic vesicle; cytoplasmic vesicle; endoplasmic reticulum lumen; mitochondrial crista; neuronal cell body; perikaryon; postsynapse; secretory granule; terminal bouton |
| Processes |
activation of phospholipase C activity; axon guidance; brain-derived neurotrophic factor receptor signaling pathway; collateral sprouting; memory; modulation of chemical synaptic transmission; negative regulation of apoptotic signaling pathway; negative regulation of myotube differentiation; negative regulation of neuron apoptotic process; nerve development; nerve growth factor signaling pathway; nervous system development; neuron projection morphogenesis; neurotrophin TRK receptor signaling pathway; peripheral nervous system development; positive regulation of brain-derived neurotrophic factor receptor signaling pathway; positive regulation of collateral sprouting; positive regulation of neuron projection development; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of receptor binding; positive regulation of synapse assembly; regulation of neuron differentiation; regulation of protein localization to cell surface; synapse assembly; transmembrane receptor protein tyrosine kinase signaling pathway; axon extension; axon target recognition; behavioral fear response; behavioral response to cocaine; circadian rhythm; dendrite development; dendrite extension; excitatory postsynaptic potential; fear response; feeding behavior; gamma-aminobutyric acid signaling pathway; glutamate secretion; inhibitory postsynaptic potential; inner ear development; learning; learning or memory; mechanoreceptor differentiation; mitochondrial electron transport; NADH to ubiquinone; negative regulation of apoptotic process; negative regulation of cell death; negative regulation of neuroblast proliferation; negative regulation of neuron death; negative regulation of striated muscle tissue development; negative regulation of synaptic transmission; GABAergic; neuron projection extension; neuron recognition; positive regulation of DNA-binding transcription factor activity; positive regulation of glucocorticoid receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron differentiation; regeneration; regulation of axon extension; regulation of collateral sprouting; regulation of long-term neuronal synaptic plasticity; regulation of metabolic process; regulation of neuron apoptotic process; regulation of retinal cell programmed cell death; regulation of short-term neuronal synaptic plasticity; regulation of synaptic plasticity; response to drug; retrograde trans-synaptic signaling by neuropeptide; modulating synaptic transmission; taste bud development; ureteric bud development |
| Common Name |
Brain derived neurotrophic factor |
