Details of family id : FD00124
| Family ID |
FD00124 |
| Protein Name |
Sortilin |
| UniProt ID |
O54861
Q99523
|
| Prosequence Length Range (aa) |
42-44
|
| Preproprotein Length Range(aa) |
825-838 |
| Preproprotein pI Range |
5.46-5.61 |
| Preproprotein Molecular Weight Range (D) |
91169.03-92067.69 |
| Prosequence pI Range (D) |
11.82-12.12 |
| Prosequence Molecular Weight Range |
4364.04-4646.31 |
| Domains |
smart00602 |
| Organisms |
Rattus norvegicus (Rat); Homo sapiens (Human) |
| Functions |
enzyme binding; G protein-coupled neurotensin receptor activity; nerve growth factor binding; nerve growth factor receptor activity; neurotensin receptor activity; non-G protein-coupled; retromer complex binding |
| Cellular Localization |
cell surface; clathrin-coated pit; clathrin-coated vesicle; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; dendrite; early endosome; endoplasmic reticulum membrane; endosome membrane; Golgi apparatus; Golgi cisterna membrane; integral component of membrane; intracellular membrane-bounded organelle; lysosomal membrane; lysosome; neuronal cell body; nuclear membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network transport vesicle |
| Processes |
endocytosis; endosome to lysosome transport; endosome transport via multivesicular body sorting pathway; extrinsic apoptotic signaling pathway via death domain receptors; G protein-coupled receptor signaling pathway; glucose import; Golgi to endosome transport; Golgi to lysosome transport; intracellular protein transport; multicellular organism development; myotube differentiation; negative regulation of fat cell differentiation; negative regulation of lipoprotein lipase activity; neuropeptide signaling pathway; neurotrophin TRK receptor signaling pathway; ossification; plasma membrane to endosome transport; positive regulation of epithelial cell apoptotic process; post-Golgi vesicle-mediated transport; protein targeting to lysosome; regulation of gene expression; response to insulin; vesicle organization |
| Common Name |
Sortilin |
