Details of family id : FD00109
| Family ID |
FD00109 |
| Protein Name |
Venom nerve growth factor 1; Neurotrophin-3; Beta-nerve growth factor |
| UniProt ID |
Q5YF90
P20181
P01139
|
| Prosequence Length Range (aa) |
103-121
|
| Preproprotein Length Range(aa) |
241-258 |
| Preproprotein pI Range |
9.24-9.56 |
| Preproprotein Molecular Weight Range (D) |
27076.71-29587.69 |
| Prosequence pI Range (D) |
8.19-10.79 |
| Prosequence Molecular Weight Range |
11622.01-13893.79 |
| Domains |
pfam00243 |
| Organisms |
Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix); Mus musculus (Mouse) |
| Functions |
growth factor activity; lipid binding; metalloendopeptidase inhibitor activity; toxin activity; chemoattractant activity; nerve growth factor binding; nerve growth factor receptor binding; neurotrophin p75 receptor binding; cysteine-type endopeptidase activator activity involved in apoptotic process; death receptor agonist activity; transmembrane receptor protein tyrosine kinase activator activity |
| Cellular Localization |
extracellular region; axon; cytoplasmic vesicle; dendrite; endoplasmic reticulum lumen; extracellular space; synaptic vesicle; endosome lumen; neuron projection terminus |
| Processes |
activation of GTPase activity; activation of MAPK activity; activation of protein kinase B activity; axon guidance; brain development; enteric nervous system development; epidermis development; generation of neurons; glial cell fate determination; induction of positive chemotaxis; mechanoreceptor differentiation; memory; modulation of chemical synaptic transmission; myelination; negative regulation of neuron apoptotic process; negative regulation of peptidyl-tyrosine phosphorylation; nerve development; nerve growth factor signaling pathway; nervous system development; neuromuscular synaptic transmission; neuron development; neuron projection morphogenesis; peripheral nervous system development; positive regulation of actin cytoskeleton reorganization; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of glial cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; regulation of neuron apoptotic process; regulation of neuron differentiation; smooth muscle cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; adult locomotory behavior; circadian rhythm; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of type B pancreatic cell apoptotic process; neuron apoptotic process; neuron projection development; positive regulation of axon extension; positive regulation of cell growth; positive regulation of collateral sprouting; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of neuron maturation; positive regulation of neuron projection development; positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of protein autophosphorylation; positive regulation of protein binding; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of Ras protein signal transduction; positive regulation of stem cell proliferation; regulation of neurotransmitter secretion; regulation of release of sequestered calcium ion into cytosol; sensory perception of pain |
| Common Name |
venom nerve growth factor; Neurotrophin; beta nerve growth factor |
